By Walter Ameling (auth.), Jürgen Meyer MD, Peter Schweizer MD, Raimund Erbel MD (eds.)
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Extra resources for Advances in Noninvasive Cardiology: Ultrasound, computed tomography, radioisotopes, digital angiography
Am J CardioI43:209-218, 1979. 4. : N-\3 ammonia as an indicator of myocardial blood flow. Circulation 63:1259-1272,1981. 5. Gould L, Schelbert HR, Phelps ME, Hoffman EJ: Noninvasive assessment of coronary stenoses by myocardial perfusion imaging during pharmacologic coronary vasodilation. V. Detection of 47 percent diameter coronary stenosis with intravenous nitrogen-I 3 ammonia and emission computed tomography in intact dogs. Am J CardioI43:200-208, 1979. 6. Schelbert HR, Wisenberg G, Phelps ME, Gould KL, Henze E, Hoffman E, Gomes A, Kuhl BE: Noninvasive assessment of coronary stenoses by myocardial imaging during pharmacologic vasodilation.
REAl. TlME - c o M P U T E R Figure 3. Graphic demonstration of the transformation of a linewise scanned videoimage series by AID conversion into a "homogeneous" block of digitized data - temporarily stored into a digital buffer - and available for further operations as desired. Figure 4. Graphic demonstration of the amount of imformation stored in a digitized block of data comparable to the average requirements in digital angiocardiography. Each picture element ("pixel") has 8 bits for gray level resolution.
The net extraction of N-13 ammonia as the product of extraction fraction and blood flow is proportional to myocardial blood flow. As shown in Figure I, this relationship is nonlinear. In the high flow range, increases in myocardial blood flow result in relatively small increments in N-13 tissue concentrations, yet flow changes within the range from 0 to 250 ml/min/IOO gm are paralleled by proportionate and almost linear increases in myocardial N-13 tissue concentrations. Accordingly, within the physiologic range of blood flow, regional differences in perfusion are reflected by proportionate differences in tracer concentrations.